PPE/HFS - Chemotherapy Side Effect Part 2

by Jamie Saphow November 16, 2017

Welcome to my second post on Palmar-Plantar Erythrodysesthesia (PPE) or Hand-Foot Syndrome (HFS) and developing a supporting solution for people who suffer from this while they struggle with chemotherapy and cancer.

My next step was to explore skin and vein support. There is some really great and thorough research in these areas. I will not list all my sources, but if you want to know more information in that regard, feel free to message me.

The first Vitamin that I decided to gather data on is Vitamin E. There are eight common isomers of this chemical, four each of tocopherol & tocotrienol. For topical application to be utilized by the skin, they must be un-esterified. Most of the Vitamin E that you can buy is esterified to help with stability of the material. 

As you age, Vitamin E decreases on your skin as your sebum production also decreases. Luckily, this material is easily obtained and applied to your skin. It can be stabilized with other antioxidant materials, such as Vitamin C (another post on that later). Vitamin E can also be sourced naturally from many fixed oils (ie. Sunflower Seed Oil).

Vitamin E and vegetables

It's theorized that Vitamin E can play a role in anti-inflammatory support of the skin. The direct mechanism of action is unknown, but this is key for me for people who suffer from PPE. 

Vitamin E will be a major part of my formula. I will utilize Sunflower Seed Oil for this reason, as well as supplement with straight Vitamin E oil itself. I have yet to identify a source of the Vitamin E that will provide me the best quality and variety of Vitamin E isomers. 

If you have any input or feedback for me, have at it! I'm open to all suggestions (and even criticism). 

I will say that if you're here to troll, then your comment will not be approved. I am happy to have some debate and discussion, but I refuse to have outright negativity and vitriol here.

One last point, please remember that I am NOT a doctor and I insist that you discuss this with your doctor(s). My goal is for you to stay healthy and whole, and any medications or other herbs you take could be contraindicated with the chemicals I discuss here.

Stay well.

These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, treat, cure or prevent any disease.


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Jamie Saphow
Jamie Saphow


Aspiring Herbalist and avid learner. I'm excited about helping people improve their lives through plants and smart life decisions. I'm studying hard to learn everything I can about plants and how they can help support a healthy body and life.

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